Drug interactions
Efavirenz + Ubrogepant
Severity: Moderate
Efavirenz and Ubrogepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may reduce ubrogepant concentrations and decrease its efficacy in acute migraine treatment. Labeling advises avoiding strong CYP3A4 inducers, and moderate inducers also warrant caution.
What this interaction means in plain words
Efavirenz and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Ubrogepant belongs to Central Nervous System.
Why it happens
Efavirenz induces CYP3A4, increasing ubrogepant clearance.
What to do
Monitor migraine response and consider an alternative acute therapy if efficacy is lost. Avoid if a suitable alternative exists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Efavirenz with Ubrogepant?
MediHelp rates the interaction as moderate. Efavirenz and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may reduce ubrogepant concentrations and decrease its efficacy in acute migraine treatment. Labeling advises avoiding strong CYP3A4 inducers, and moderate inducers also warrant caution.
How serious is the interaction between Efavirenz and Ubrogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor migraine response and consider an alternative acute therapy if efficacy is lost. Avoid if a suitable alternative exists.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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