Drug interactions
Efavirenz + Vilazodone
Severity: Moderate
Efavirenz and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz is a CYP3A4 inducer and can reduce vilazodone exposure, which may lead to loss of antidepressant effect.
What this interaction means in plain words
Efavirenz and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Vilazodone belongs to Central Nervous System.
Why it happens
Efavirenz induces CYP3A4, the main metabolic pathway of vilazodone, increasing its clearance.
What to do
Monitor for loss of antidepressant response. Consider increasing the vilazodone dose, within the labeled maximum, and reduce it again after efavirenz is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Efavirenz with Vilazodone?
MediHelp rates the interaction as moderate. Efavirenz and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz is a CYP3A4 inducer and can reduce vilazodone exposure, which may lead to loss of antidepressant effect.
How serious is the interaction between Efavirenz and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antidepressant response. Consider increasing the vilazodone dose, within the labeled maximum, and reduce it again after efavirenz is stopped.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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