Drug interactions
Elacestrant + Modafinil
Severity: Moderate
Elacestrant and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elacestrant is metabolised mainly by CYP3A4, and modafinil's CYP3A4 induction may reduce its exposure. This could weaken the anticancer effect.
What this interaction means in plain words
Elacestrant and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elacestrant belongs to Oncology; Modafinil belongs to Central Nervous System.
Why it happens
Modafinil induces CYP3A4, increasing elacestrant clearance.
What to do
Prefer a wakefulness agent that does not induce CYP3A4. If it must be used, monitor disease response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Modafinil?
MediHelp rates the interaction as moderate. Elacestrant and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elacestrant is metabolised mainly by CYP3A4, and modafinil's CYP3A4 induction may reduce its exposure. This could weaken the anticancer effect.
How serious is the interaction between Elacestrant and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a wakefulness agent that does not induce CYP3A4. If it must be used, monitor disease response.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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