Drug interactions
Elacestrant + Temsirolimus
Severity: Minor
Elacestrant and Temsirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elacestrant inhibits P-glycoprotein and could modestly raise temsirolimus exposure. The clinical significance is uncertain because temsirolimus is mainly cleared by CYP3A4.
What this interaction means in plain words
Elacestrant and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elacestrant belongs to Oncology; Temsirolimus belongs to Oncology.
Why it happens
Elacestrant inhibits intestinal P-gp efflux, which may modestly increase temsirolimus exposure.
What to do
No routine dose change is needed; monitor for temsirolimus adverse effects such as stomatitis, rash and cytopenias.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Temsirolimus?
MediHelp rates the interaction as minor. Elacestrant and Temsirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elacestrant inhibits P-glycoprotein and could modestly raise temsirolimus exposure. The clinical significance is uncertain because temsirolimus is mainly cleared by CYP3A4.
How serious is the interaction between Elacestrant and Temsirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for temsirolimus adverse effects such as stomatitis, rash and cytopenias.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
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