Drug interactions
Elafibranor + Levonorgestrel
Severity: Minor
Elafibranor and Levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elafibranor weakly induces CYP3A4, and the label recommends progestin-only methods such as levonorgestrel as an option for women needing contraception. Any reduction in levonorgestrel exposure is expected to be small, but efficacy of emergency or oral dosing is not well studied.
What this interaction means in plain words
Elafibranor and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elafibranor belongs to Gastrointestinal Tract; Levonorgestrel belongs to Endocrine.
Why it happens
Weak CYP3A4 induction by elafibranor could modestly increase levonorgestrel metabolism.
What to do
Levonorgestrel-based contraception is an acceptable option; consider a reliable additional or intrauterine method if there is concern about efficacy. Continue contraception for at least 3 weeks after stopping elafibranor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Elafibranor
- Elafibranor + Gemfibrozil Major
- Elafibranor + Estradiol Moderate
- Elafibranor + Fenofibrate Moderate
- Elafibranor + Pioglitazone Moderate
- Elafibranor + Rifampicin Moderate
- Elafibranor + Rosiglitazone Moderate
Other interactions of Levonorgestrel
Frequently asked questions
Can I take Elafibranor with Levonorgestrel?
MediHelp rates the interaction as minor. Elafibranor and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elafibranor weakly induces CYP3A4, and the label recommends progestin-only methods such as levonorgestrel as an option for women needing contraception. Any reduction in levonorgestrel exposure is expected to be small, but efficacy of emergency or oral dosing is not well studied.
How serious is the interaction between Elafibranor and Levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Levonorgestrel-based contraception is an acceptable option; consider a reliable additional or intrauterine method if there is concern about efficacy. Continue contraception for at least 3 weeks after stopping elafibranor.
What other medicines interact with Elafibranor?
MediHelp also lists interactions of Elafibranor with, for example, Gemfibrozil, Estradiol, Fenofibrate. The full list is on the Elafibranor page.
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