Drug interactions
Elafibranor + Rifampicin
Severity: Moderate
Elafibranor and Rifampicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin may lower elafibranor exposure and reduce its biochemical response in cholangitis. Loss of efficacy could allow cholestasis markers to worsen.
What this interaction means in plain words
Elafibranor and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elafibranor belongs to Gastrointestinal Tract; Rifampicin belongs to Anti Bacterial.
Why it happens
Rifampicin induces metabolic enzymes and transporters, increasing elafibranor clearance.
What to do
Monitor alkaline phosphatase and bilirubin when starting rifampicin, and reassess elafibranor response. Consider an alternative anti-infective if response declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Elafibranor
- Elafibranor + Gemfibrozil Major
- Elafibranor + Estradiol Moderate
- Elafibranor + Fenofibrate Moderate
- Elafibranor + Pioglitazone Moderate
- Elafibranor + Rosiglitazone Moderate
- Elafibranor + Levonorgestrel Minor
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Elafibranor with Rifampicin?
MediHelp rates the interaction as moderate. Elafibranor and Rifampicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampicin may lower elafibranor exposure and reduce its biochemical response in cholangitis. Loss of efficacy could allow cholestasis markers to worsen.
How serious is the interaction between Elafibranor and Rifampicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor alkaline phosphatase and bilirubin when starting rifampicin, and reassess elafibranor response. Consider an alternative anti-infective if response declines.
What other medicines interact with Elafibranor?
MediHelp also lists interactions of Elafibranor with, for example, Gemfibrozil, Estradiol, Fenofibrate. The full list is on the Elafibranor page.
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