Drug interactions
Elafibranor + Estradiol
Severity: Moderate
Elafibranor and Estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elafibranor is a weak CYP3A4 inducer and lowers exposure to ethinylestradiol-containing contraceptives, which may reduce their reliability. Estradiol as a CYP3A4 substrate could be affected similarly, reducing hormonal efficacy.
What this interaction means in plain words
Elafibranor and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elafibranor belongs to Gastrointestinal Tract; Estradiol belongs to Endocrine.
Why it happens
Elafibranor induces CYP3A4, increasing hepatic metabolism of estrogens.
What to do
For contraception, use a progestin-only, intrauterine or non-hormonal method during treatment and for at least 3 weeks after the last dose. For menopausal estradiol therapy, monitor symptom control and adjust the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Elafibranor
- Elafibranor + Gemfibrozil Major
- Elafibranor + Fenofibrate Moderate
- Elafibranor + Pioglitazone Moderate
- Elafibranor + Rifampicin Moderate
- Elafibranor + Rosiglitazone Moderate
- Elafibranor + Levonorgestrel Minor
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Elafibranor with Estradiol?
MediHelp rates the interaction as moderate. Elafibranor and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elafibranor is a weak CYP3A4 inducer and lowers exposure to ethinylestradiol-containing contraceptives, which may reduce their reliability. Estradiol as a CYP3A4 substrate could be affected similarly, reducing hormonal efficacy.
How serious is the interaction between Elafibranor and Estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For contraception, use a progestin-only, intrauterine or non-hormonal method during treatment and for at least 3 weeks after the last dose. For menopausal estradiol therapy, monitor symptom control and adjust the dose if needed.
What other medicines interact with Elafibranor?
MediHelp also lists interactions of Elafibranor with, for example, Gemfibrozil, Fenofibrate, Pioglitazone. The full list is on the Elafibranor page.
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