Drug interactions
Elafibranor + Gemfibrozil
Severity: Major
Elafibranor and Gemfibrozil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil strongly inhibits CYP2C8 and may raise exposure to elafibranor's active metabolite. This could increase adverse effects such as muscle toxicity and liver effects.
What this interaction means in plain words
Elafibranor and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elafibranor belongs to Gastrointestinal Tract; Gemfibrozil belongs to Cardiovascular.
Why it happens
CYP2C8 inhibition by gemfibrozil reduces clearance of elafibranor's active metabolite.
What to do
Avoid the combination. If it is unavoidable, monitor for muscle symptoms, liver tests and other adverse reactions.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Elafibranor and Gemfibrozil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Elafibranor
- Elafibranor + Estradiol Moderate
- Elafibranor + Fenofibrate Moderate
- Elafibranor + Pioglitazone Moderate
- Elafibranor + Rifampicin Moderate
- Elafibranor + Rosiglitazone Moderate
- Elafibranor + Levonorgestrel Minor
Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Frequently asked questions
Can I take Elafibranor with Gemfibrozil?
MediHelp rates the interaction as major. Elafibranor and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil strongly inhibits CYP2C8 and may raise exposure to elafibranor's active metabolite. This could increase adverse effects such as muscle toxicity and liver effects.
How serious is the interaction between Elafibranor and Gemfibrozil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If it is unavoidable, monitor for muscle symptoms, liver tests and other adverse reactions.
What other medicines interact with Elafibranor?
MediHelp also lists interactions of Elafibranor with, for example, Estradiol, Fenofibrate, Pioglitazone. The full list is on the Elafibranor page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
