Drug interactions
Elafibranor + Fenofibrate
Severity: Moderate
Elafibranor and Fenofibrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs activate PPAR-alpha, so combining them may add to the risk of hepatic injury and muscle toxicity. There is no additional lipid-lowering or other benefit that clearly justifies duplication.
What this interaction means in plain words
Elafibranor and Fenofibrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elafibranor belongs to Gastrointestinal Tract; Fenofibrate belongs to Cardiovascular.
Why it happens
Additive PPAR-alpha agonist pharmacodynamic effects on liver and muscle.
What to do
Avoid concurrent use where possible; if combined, monitor liver tests and creatine kinase and watch for myalgia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Elafibranor
- Elafibranor + Gemfibrozil Major
- Elafibranor + Estradiol Moderate
- Elafibranor + Pioglitazone Moderate
- Elafibranor + Rifampicin Moderate
- Elafibranor + Rosiglitazone Moderate
- Elafibranor + Levonorgestrel Minor
Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Frequently asked questions
Can I take Elafibranor with Fenofibrate?
MediHelp rates the interaction as moderate. Elafibranor and Fenofibrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs activate PPAR-alpha, so combining them may add to the risk of hepatic injury and muscle toxicity. There is no additional lipid-lowering or other benefit that clearly justifies duplication.
How serious is the interaction between Elafibranor and Fenofibrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if combined, monitor liver tests and creatine kinase and watch for myalgia.
What other medicines interact with Elafibranor?
MediHelp also lists interactions of Elafibranor with, for example, Gemfibrozil, Estradiol, Pioglitazone. The full list is on the Elafibranor page.
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