Drug interactions
Elafibranor + Pioglitazone
Severity: Moderate
Elafibranor and Pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elafibranor is a PPAR-alpha/delta agonist, and combining it with PPAR-gamma agonists such as pioglitazone may increase the risk of hepatic injury. Both drugs may also affect fluid balance and liver enzymes.
What this interaction means in plain words
Elafibranor and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elafibranor belongs to Gastrointestinal Tract; Pioglitazone belongs to Endocrine.
Why it happens
Additive PPAR agonism with overlapping hepatotoxic potential; the exact mechanism is not fully established.
What to do
Monitor liver tests regularly during combined use and stop one agent if liver enzymes or bilirubin rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Elafibranor
- Elafibranor + Gemfibrozil Major
- Elafibranor + Estradiol Moderate
- Elafibranor + Fenofibrate Moderate
- Elafibranor + Rifampicin Moderate
- Elafibranor + Rosiglitazone Moderate
- Elafibranor + Levonorgestrel Minor
Other interactions of Pioglitazone
Frequently asked questions
Can I take Elafibranor with Pioglitazone?
MediHelp rates the interaction as moderate. Elafibranor and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elafibranor is a PPAR-alpha/delta agonist, and combining it with PPAR-gamma agonists such as pioglitazone may increase the risk of hepatic injury. Both drugs may also affect fluid balance and liver enzymes.
How serious is the interaction between Elafibranor and Pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver tests regularly during combined use and stop one agent if liver enzymes or bilirubin rise significantly.
What other medicines interact with Elafibranor?
MediHelp also lists interactions of Elafibranor with, for example, Gemfibrozil, Estradiol, Fenofibrate. The full list is on the Elafibranor page.
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