Drug interactions
Elafibranor + Norgestrel
Severity: Minor
Elafibranor and Norgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elafibranor weakly induces CYP3A4 and the label suggests progestin-only contraceptives as an alternative to ethinylestradiol products. Reduced norgestrel exposure is theoretically possible but expected to be small.
What this interaction means in plain words
Elafibranor and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elafibranor belongs to Gastrointestinal Tract; Norgestrel belongs to Endocrine.
Why it happens
Weak CYP3A4 induction by elafibranor may slightly increase norgestrel metabolism.
What to do
Norgestrel-based contraception can be used; consider an intrauterine or additional barrier method if needed. Continue contraception for at least 3 weeks after the last elafibranor dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Elafibranor
- Elafibranor + Gemfibrozil Major
- Elafibranor + Estradiol Moderate
- Elafibranor + Fenofibrate Moderate
- Elafibranor + Pioglitazone Moderate
- Elafibranor + Rifampicin Moderate
- Elafibranor + Rosiglitazone Moderate
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Elafibranor with Norgestrel?
MediHelp rates the interaction as minor. Elafibranor and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elafibranor weakly induces CYP3A4 and the label suggests progestin-only contraceptives as an alternative to ethinylestradiol products. Reduced norgestrel exposure is theoretically possible but expected to be small.
How serious is the interaction between Elafibranor and Norgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Norgestrel-based contraception can be used; consider an intrauterine or additional barrier method if needed. Continue contraception for at least 3 weeks after the last elafibranor dose.
What other medicines interact with Elafibranor?
MediHelp also lists interactions of Elafibranor with, for example, Gemfibrozil, Estradiol, Fenofibrate. The full list is on the Elafibranor page.
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