Drug interactions
Elagolix + Hydrochlorothiazide-telmisartan
Severity: Minor
Elagolix and Hydrochlorothiazide-telmisartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan may inhibit OATP1B1 and raise elagolix exposure, but it is not a recognized strong OATP1B1 inhibitor like cyclosporine or rifampin. The effect is likely modest, with possible increased elagolix adverse effects such as hot flushes or liver enzyme elevation.
What this interaction means in plain words
Elagolix and Hydrochlorothiazide-telmisartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Possible weak inhibition of OATP1B1-mediated hepatic uptake of elagolix; not firmly established.
What to do
No routine change is needed; monitor for elagolix adverse effects and liver tests if used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as minor. Elagolix and Hydrochlorothiazide-telmisartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Telmisartan may inhibit OATP1B1 and raise elagolix exposure, but it is not a recognized strong OATP1B1 inhibitor like cyclosporine or rifampin. The effect is likely modest, with possible increased elagolix adverse effects such as hot flushes or liver enzyme elevation.
How serious is the interaction between Elagolix and Hydrochlorothiazide-telmisartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for elagolix adverse effects and liver tests if used long term.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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