Drug interactions
Elagolix + Imipramine
Severity: Minor
Elagolix and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak CYP2C19 inhibitor and may modestly raise imipramine exposure, since CYP2C19 contributes to its demethylation to desipramine. The effect is usually small, but anticholinergic or cardiac effects may increase in sensitive patients.
What this interaction means in plain words
Elagolix and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Imipramine belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP2C19-mediated imipramine metabolism by elagolix.
What to do
No routine dose change is needed. Watch for anticholinergic effects, sedation or palpitations and reduce the imipramine dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Imipramine?
MediHelp rates the interaction as minor. Elagolix and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak CYP2C19 inhibitor and may modestly raise imipramine exposure, since CYP2C19 contributes to its demethylation to desipramine. The effect is usually small, but anticholinergic or cardiac effects may increase in sensitive patients.
How serious is the interaction between Elagolix and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for anticholinergic effects, sedation or palpitations and reduce the imipramine dose if they occur.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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