Drug interactions
Elagolix + Irinotecan
Severity: Minor
Elagolix and Irinotecan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak to moderate CYP3A4 inducer and a P-gp inhibitor. The net effect on irinotecan is uncertain: induction may lower exposure to irinotecan and its active metabolite, while P-gp inhibition may raise it.
What this interaction means in plain words
Elagolix and Irinotecan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Irinotecan belongs to Oncology.
Why it happens
Opposing effects of CYP3A4 induction and P-gp inhibition on irinotecan disposition.
What to do
Monitor treatment response and toxicity (diarrhea, neutropenia), adjusting the irinotecan dose as clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Irinotecan?
MediHelp rates the interaction as minor. Elagolix and Irinotecan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak to moderate CYP3A4 inducer and a P-gp inhibitor. The net effect on irinotecan is uncertain: induction may lower exposure to irinotecan and its active metabolite, while P-gp inhibition may raise it.
How serious is the interaction between Elagolix and Irinotecan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response and toxicity (diarrhea, neutropenia), adjusting the irinotecan dose as clinically indicated.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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