Drug interactions
Elagolix + Ledipasvir-sofosbuvir
Severity: Minor
Elagolix and Ledipasvir-sofosbuvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix may inhibit intestinal P-gp and increase exposure to ledipasvir and sofosbuvir. The increase is expected to be small and tolerable.
What this interaction means in plain words
Elagolix and Ledipasvir-sofosbuvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Ledipasvir-sofosbuvir belongs to Anti Virals.
Why it happens
P-gp inhibition by elagolix reduces efflux of ledipasvir and sofosbuvir.
What to do
No dose adjustment is needed; monitor for antiviral adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Elagolix and Ledipasvir-sofosbuvir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Ledipasvir-sofosbuvir?
MediHelp rates the interaction as minor. Elagolix and Ledipasvir-sofosbuvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix may inhibit intestinal P-gp and increase exposure to ledipasvir and sofosbuvir. The increase is expected to be small and tolerable.
How serious is the interaction between Elagolix and Ledipasvir-sofosbuvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for antiviral adverse effects.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
