Drug interactions
Elagolix + Levonorgestrel
Severity: Moderate
Elagolix and Levonorgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a GnRH antagonist, and hormonal contraceptives may theoretically blunt its efficacy. Evidence for progestin-only methods is lacking, and an intrauterine system has low systemic exposure.
What this interaction means in plain words
Elagolix and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Levonorgestrel belongs to Endocrine.
Why it happens
Possible pharmacodynamic opposition at the hormonal axis; not firmly established for progestin-only products.
What to do
Labeling advises nonhormonal contraception during elagolix and for 1 week after stopping. Monitor symptom control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Elagolix and Levonorgestrel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Levonorgestrel
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Levonorgestrel?
MediHelp rates the interaction as moderate. Elagolix and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a GnRH antagonist, and hormonal contraceptives may theoretically blunt its efficacy. Evidence for progestin-only methods is lacking, and an intrauterine system has low systemic exposure.
How serious is the interaction between Elagolix and Levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Labeling advises nonhormonal contraception during elagolix and for 1 week after stopping. Monitor symptom control.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
