Drug interactions
Elagolix + Lorlatinib
Severity: Moderate
Elagolix and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may lower elagolix levels, reducing control of endometriosis or fibroid symptoms. Elagolix is itself a weak-to-moderate CYP3A4 inducer, so lorlatinib exposure may fall as well.
What this interaction means in plain words
Elagolix and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Lorlatinib belongs to Oncology.
Why it happens
Both drugs induce CYP3A4, and each is a CYP3A4 substrate.
What to do
Monitor for reduced symptom control with elagolix. Also monitor lorlatinib efficacy, since its exposure may decline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Lorlatinib?
MediHelp rates the interaction as moderate. Elagolix and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib may lower elagolix levels, reducing control of endometriosis or fibroid symptoms. Elagolix is itself a weak-to-moderate CYP3A4 inducer, so lorlatinib exposure may fall as well.
How serious is the interaction between Elagolix and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced symptom control with elagolix. Also monitor lorlatinib efficacy, since its exposure may decline.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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