Drug interactions
Elagolix + Morphine
Severity: Minor
Elagolix and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix can inhibit intestinal P-glycoprotein, and morphine is a P-gp substrate. Morphine exposure may rise modestly, increasing the potential for sedation and respiratory depression.
What this interaction means in plain words
Elagolix and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Morphine belongs to Musculoskeletal.
Why it happens
Inhibition of P-glycoprotein efflux, which may increase morphine absorption and CNS penetration.
What to do
Monitor for increased opioid effects such as sedation and slowed breathing, and reduce the morphine dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Morphine?
MediHelp rates the interaction as minor. Elagolix and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix can inhibit intestinal P-glycoprotein, and morphine is a P-gp substrate. Morphine exposure may rise modestly, increasing the potential for sedation and respiratory depression.
How serious is the interaction between Elagolix and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased opioid effects such as sedation and slowed breathing, and reduce the morphine dose if these occur.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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