Drug interactions
Elagolix + Nifedipine
Severity: Minor
Elagolix and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak to moderate CYP3A4 inducer and may lower nifedipine concentrations. The effect on blood pressure control is usually modest.
What this interaction means in plain words
Elagolix and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Nifedipine belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 by elagolix increases nifedipine metabolism.
What to do
Monitor blood pressure after elagolix is started or stopped. Increase the nifedipine dose if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Nifedipine?
MediHelp rates the interaction as minor. Elagolix and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak to moderate CYP3A4 inducer and may lower nifedipine concentrations. The effect on blood pressure control is usually modest.
How serious is the interaction between Elagolix and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after elagolix is started or stopped. Increase the nifedipine dose if control is lost.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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