Drug interactions
Elagolix + Pantoprazole
Severity: Minor
Elagolix and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak CYP2C19 inhibitor and may modestly raise pantoprazole concentrations. The effect is unlikely to be clinically important given pantoprazole's wide therapeutic margin.
What this interaction means in plain words
Elagolix and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Weak inhibition of CYP2C19 by elagolix reduces pantoprazole metabolism.
What to do
No dose change is usually required. Be aware of possible increased PPI adverse effects with long-term co-use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Pantoprazole?
MediHelp rates the interaction as minor. Elagolix and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak CYP2C19 inhibitor and may modestly raise pantoprazole concentrations. The effect is unlikely to be clinically important given pantoprazole's wide therapeutic margin.
How serious is the interaction between Elagolix and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Be aware of possible increased PPI adverse effects with long-term co-use.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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