Drug interactions
Elagolix + Quinine
Severity: Moderate
Elagolix and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer and may lower quinine concentrations, risking reduced antimalarial efficacy. It also inhibits P-gp, which could raise exposure, so the net effect is uncertain.
What this interaction means in plain words
Elagolix and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Quinine belongs to Anti Parasitic.
Why it happens
Elagolix induces CYP3A4 and inhibits P-glycoprotein, with opposing effects on quinine exposure.
What to do
Monitor treatment response when quinine is used for malaria, and watch for quinine toxicity. Adjust therapy based on clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Quinine?
MediHelp rates the interaction as moderate. Elagolix and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak-to-moderate CYP3A4 inducer and may lower quinine concentrations, risking reduced antimalarial efficacy. It also inhibits P-gp, which could raise exposure, so the net effect is uncertain.
How serious is the interaction between Elagolix and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response when quinine is used for malaria, and watch for quinine toxicity. Adjust therapy based on clinical response.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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