Drug interactions
Elagolix + Tolterodine
Severity: Minor
Elagolix and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer that may lower tolterodine concentrations. Because tolterodine is mostly cleared by CYP2D6 in most patients, the effect is usually modest.
What this interaction means in plain words
Elagolix and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Tolterodine belongs to Genitourinary.
Why it happens
CYP3A4 induction by elagolix increases tolterodine metabolism.
What to do
Monitor for reduced response to tolterodine and increase the dose if symptoms are not controlled.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Tolterodine?
MediHelp rates the interaction as minor. Elagolix and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak-to-moderate CYP3A4 inducer that may lower tolterodine concentrations. Because tolterodine is mostly cleared by CYP2D6 in most patients, the effect is usually modest.
How serious is the interaction between Elagolix and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to tolterodine and increase the dose if symptoms are not controlled.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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