Drug interactions
Elagolix + Vincristine
Severity: Minor
Elagolix and Vincristine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak to moderate CYP3A inducer and a P-glycoprotein inhibitor, so effects on vincristine exposure are uncertain and may offset each other. The clinical significance is likely small and the combination is rarely used.
What this interaction means in plain words
Elagolix and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Vincristine belongs to Oncology.
Why it happens
Opposing effects of weak CYP3A induction and P-glycoprotein inhibition on vincristine clearance.
What to do
Monitor vincristine response and toxicity such as neuropathy. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Vincristine?
MediHelp rates the interaction as minor. Elagolix and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak to moderate CYP3A inducer and a P-glycoprotein inhibitor, so effects on vincristine exposure are uncertain and may offset each other. The clinical significance is likely small and the combination is rarely used.
How serious is the interaction between Elagolix and Vincristine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor vincristine response and toxicity such as neuropathy. No routine dose change is needed.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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