Drug interactions
Elagolix + Vinorelbine
Severity: Moderate
Elagolix and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer and could lower vinorelbine concentrations. The clinical effect is uncertain but could reduce efficacy.
What this interaction means in plain words
Elagolix and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Vinorelbine belongs to Oncology.
Why it happens
Elagolix induces CYP3A4, increasing vinorelbine metabolism.
What to do
Review the need for elagolix during chemotherapy and consider alternatives. If used, monitor response to vinorelbine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Vinorelbine?
MediHelp rates the interaction as moderate. Elagolix and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak-to-moderate CYP3A4 inducer and could lower vinorelbine concentrations. The clinical effect is uncertain but could reduce efficacy.
How serious is the interaction between Elagolix and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the need for elagolix during chemotherapy and consider alternatives. If used, monitor response to vinorelbine.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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