Drug interactions
Eletriptan + Hydrocodone
Severity: Moderate
Eletriptan and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans and opioids both have serotonergic activity, and serotonin syndrome has been reported with such combinations. The risk is low but is greatest after starting or increasing a dose.
What this interaction means in plain words
Eletriptan and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Hydrocodone belongs to Musculoskeletal.
Why it happens
Additive serotonergic effects at 5-HT receptors and monoamine transmission.
What to do
Monitor for signs of serotonin syndrome when combining. Stop both and treat supportively if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Hydrocodone?
MediHelp rates the interaction as moderate. Eletriptan and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans and opioids both have serotonergic activity, and serotonin syndrome has been reported with such combinations. The risk is low but is greatest after starting or increasing a dose.
How serious is the interaction between Eletriptan and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome when combining. Stop both and treat supportively if it occurs.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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