Drug interactions
Eletriptan + Lapatinib
Severity: Moderate
Eletriptan and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and may increase eletriptan concentrations. This could amplify triptan adverse effects such as blood pressure elevation and chest tightness.
What this interaction means in plain words
Eletriptan and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Lapatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated eletriptan metabolism by lapatinib.
What to do
Use the lowest effective eletriptan dose and monitor blood pressure and adverse effects. Consider a triptan not dependent on CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Eletriptan with Lapatinib?
MediHelp rates the interaction as moderate. Eletriptan and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP3A4 and may increase eletriptan concentrations. This could amplify triptan adverse effects such as blood pressure elevation and chest tightness.
How serious is the interaction between Eletriptan and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective eletriptan dose and monitor blood pressure and adverse effects. Consider a triptan not dependent on CYP3A4.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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