Drug interactions
Eletriptan + Lenacapavir
Severity: Moderate
Eletriptan and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor and may increase eletriptan exposure, with the effect lasting months after subcutaneous dosing. This raises the risk of triptan adverse effects.
What this interaction means in plain words
Eletriptan and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Lenacapavir belongs to Anti Virals.
Why it happens
Moderate inhibition of CYP3A4-mediated metabolism of eletriptan.
What to do
Use eletriptan at a reduced dose and limit frequency, monitoring blood pressure. Consider a triptan not metabolized by CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Eletriptan with Lenacapavir?
MediHelp rates the interaction as moderate. Eletriptan and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A4 inhibitor and may increase eletriptan exposure, with the effect lasting months after subcutaneous dosing. This raises the risk of triptan adverse effects.
How serious is the interaction between Eletriptan and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use eletriptan at a reduced dose and limit frequency, monitoring blood pressure. Consider a triptan not metabolized by CYP3A4.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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