Drug interactions
Eletriptan + Loxapine
Severity: Moderate
Eletriptan and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both serotonergic activity and dopamine blockade are involved, so there is a theoretical risk of serotonin syndrome when an antipsychotic is combined with a triptan. Reports of clinically significant events are rare and the evidence is limited. Loxapine also has a small risk of neuroleptic malignant syndrome, which presents with overlapping features.
What this interaction means in plain words
Eletriptan and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Loxapine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects through 5-HT receptor activity; the interaction is largely theoretical and not firmly established.
What to do
Counsel the patient to report agitation, tremor, fever, sweating or muscle rigidity promptly. Monitor for serotonin toxicity or neuroleptic malignant syndrome after starting or changing doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Loxapine?
MediHelp rates the interaction as moderate. Eletriptan and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both serotonergic activity and dopamine blockade are involved, so there is a theoretical risk of serotonin syndrome when an antipsychotic is combined with a triptan. Reports of clinically significant events are rare and the evidence is limited. Loxapine also has a small risk of neuroleptic malignant syndrome, which presents with overlapping features.
How serious is the interaction between Eletriptan and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, tremor, fever, sweating or muscle rigidity promptly. Monitor for serotonin toxicity or neuroleptic malignant syndrome after starting or changing doses.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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