Drug interactions
Eletriptan + Maprotiline
Severity: Moderate
Eletriptan and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of a serotonergic antidepressant and a triptan carries a reported but uncommon risk of serotonin syndrome. Maprotiline has weak serotonergic activity, so the risk is likely small.
What this interaction means in plain words
Eletriptan and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from triptan 5-HT1B/1D agonism and monoamine reuptake inhibition.
What to do
Advise the patient to report symptoms of serotonin toxicity, and monitor closely when starting or increasing either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Maprotiline?
MediHelp rates the interaction as moderate. Eletriptan and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of a serotonergic antidepressant and a triptan carries a reported but uncommon risk of serotonin syndrome. Maprotiline has weak serotonergic activity, so the risk is likely small.
How serious is the interaction between Eletriptan and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to report symptoms of serotonin toxicity, and monitor closely when starting or increasing either drug.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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