Drug interactions
Eletriptan + Mitotane
Severity: Moderate
Eletriptan and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and can substantially reduce eletriptan exposure, with the effect persisting for weeks after mitotane is stopped. Migraine treatment may become ineffective.
What this interaction means in plain words
Eletriptan and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Mitotane belongs to Oncology.
Why it happens
Strong induction of CYP3A4 increases eletriptan clearance.
What to do
Monitor for loss of efficacy and consider a triptan not dependent on CYP3A4. Higher eletriptan doses should not exceed labeled limits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Eletriptan with Mitotane?
MediHelp rates the interaction as moderate. Eletriptan and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and can substantially reduce eletriptan exposure, with the effect persisting for weeks after mitotane is stopped. Migraine treatment may become ineffective.
How serious is the interaction between Eletriptan and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of efficacy and consider a triptan not dependent on CYP3A4. Higher eletriptan doses should not exceed labeled limits.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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