Drug interactions
Eletriptan + Oliceridine
Severity: Moderate
Eletriptan and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is an opioid and opioids with serotonergic activity have been linked to serotonin syndrome when combined with triptans. The risk with oliceridine is probably low but cannot be excluded.
What this interaction means in plain words
Eletriptan and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Possible additive serotonergic effects; mechanism for oliceridine is not well established.
What to do
Monitor for agitation, tremor, hyperthermia or clonus when used together, and discontinue if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Eletriptan with Oliceridine?
MediHelp rates the interaction as moderate. Eletriptan and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is an opioid and opioids with serotonergic activity have been linked to serotonin syndrome when combined with triptans. The risk with oliceridine is probably low but cannot be excluded.
How serious is the interaction between Eletriptan and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia or clonus when used together, and discontinue if serotonin syndrome is suspected.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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