Drug interactions
Eletriptan + Procarbazine
Severity: Moderate
Eletriptan and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak MAO-inhibiting properties, and combining it with eletriptan may increase the risk of serotonin syndrome. The risk is largely theoretical, as eletriptan is metabolized mainly by CYP3A4.
What this interaction means in plain words
Eletriptan and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Additive serotonergic effects via procarbazine's MAO inhibition and triptan 5-HT1B/1D agonism.
What to do
Monitor for signs of serotonin toxicity such as agitation, tremor, sweating and hyperreflexia. Choose a non-serotonergic migraine therapy if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Eletriptan with Procarbazine?
MediHelp rates the interaction as moderate. Eletriptan and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak MAO-inhibiting properties, and combining it with eletriptan may increase the risk of serotonin syndrome. The risk is largely theoretical, as eletriptan is metabolized mainly by CYP3A4.
How serious is the interaction between Eletriptan and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity such as agitation, tremor, sweating and hyperreflexia. Choose a non-serotonergic migraine therapy if possible.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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