Drug interactions
Eletriptan + Quetiapine
Severity: Moderate
Eletriptan and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics with serotonin receptor activity and triptans may rarely contribute to serotonin syndrome when combined. The clinical risk is considered low, but patients should be aware of symptoms such as agitation, tremor, hyperthermia and autonomic instability.
What this interaction means in plain words
Eletriptan and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects via 5-HT1B/1D agonism and quetiapine 5-HT receptor activity; the mechanism is largely theoretical.
What to do
The combination can be used when needed; counsel the patient on serotonin syndrome symptoms and review use if they appear. Monitor for mental status changes, neuromuscular hyperactivity and fever, particularly after dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Quetiapine?
MediHelp rates the interaction as moderate. Eletriptan and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antipsychotics with serotonin receptor activity and triptans may rarely contribute to serotonin syndrome when combined. The clinical risk is considered low, but patients should be aware of symptoms such as agitation, tremor, hyperthermia and autonomic instability.
How serious is the interaction between Eletriptan and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination can be used when needed; counsel the patient on serotonin syndrome symptoms and review use if they appear. Monitor for mental status changes, neuromuscular hyperactivity and fever, particularly after dose changes.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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