Drug interactions
Eletriptan + Sertraline
Severity: Moderate
Eletriptan and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent SSRI and triptan use has been linked to rare serotonin syndrome reports. The absolute risk is low, and eletriptan is not meaningfully affected by sertraline pharmacokinetically.
What this interaction means in plain words
Eletriptan and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive serotonergic effects.
What to do
Educate the patient about serotonin syndrome symptoms and use the lowest effective eletriptan dose. Discontinue the triptan and seek care if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Sertraline?
MediHelp rates the interaction as moderate. Eletriptan and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent SSRI and triptan use has been linked to rare serotonin syndrome reports. The absolute risk is low, and eletriptan is not meaningfully affected by sertraline pharmacokinetically.
How serious is the interaction between Eletriptan and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Educate the patient about serotonin syndrome symptoms and use the lowest effective eletriptan dose. Discontinue the triptan and seek care if symptoms develop.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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