Drug interactions
Eletriptan + Verapamil
Severity: Moderate
Eletriptan and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eletriptan is extensively metabolized by CYP3A4, and verapamil, a moderate CYP3A4 inhibitor, raises its levels. Strong CYP3A4 inhibitors are contraindicated with eletriptan, while moderate inhibitors produce a smaller increase. Higher exposure may increase vasoconstrictive and blood pressure effects.
What this interaction means in plain words
Eletriptan and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4, reducing first-pass and systemic clearance of eletriptan.
What to do
Use the lowest effective eletriptan dose and do not repeat dosing within 24 hours of the initial dose beyond labeled limits. Monitor blood pressure and for chest tightness or other adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Verapamil?
MediHelp rates the interaction as moderate. Eletriptan and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eletriptan is extensively metabolized by CYP3A4, and verapamil, a moderate CYP3A4 inhibitor, raises its levels. Strong CYP3A4 inhibitors are contraindicated with eletriptan, while moderate inhibitors produce a smaller increase. Higher exposure may increase vasoconstrictive and blood pressure effects.
How serious is the interaction between Eletriptan and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective eletriptan dose and do not repeat dosing within 24 hours of the initial dose beyond labeled limits. Monitor blood pressure and for chest tightness or other adverse effects.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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