Drug interactions
Eletriptan + Voxelotor
Severity: Moderate
Eletriptan and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and can raise exposure to sensitive CYP3A4 substrates such as eletriptan. Higher eletriptan levels may increase triptan adverse effects including vasoconstriction, hypertension and chest symptoms.
What this interaction means in plain words
Eletriptan and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits intestinal and hepatic CYP3A4, reducing the first-pass and systemic metabolism of eletriptan.
What to do
Avoid the combination if a suitable alternative triptan not metabolized by CYP3A4 is available. If used together, consider a reduced eletriptan dose and monitor blood pressure and cardiovascular symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Eletriptan with Voxelotor?
MediHelp rates the interaction as moderate. Eletriptan and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and can raise exposure to sensitive CYP3A4 substrates such as eletriptan. Higher eletriptan levels may increase triptan adverse effects including vasoconstriction, hypertension and chest symptoms.
How serious is the interaction between Eletriptan and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if a suitable alternative triptan not metabolized by CYP3A4 is available. If used together, consider a reduced eletriptan dose and monitor blood pressure and cardiovascular symptoms.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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