Drug interactions
Eletriptan + Zafirlukast
Severity: Minor
Eletriptan and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eletriptan is a sensitive CYP3A4 substrate, and strong inhibitors are contraindicated. Zafirlukast is only a weak inhibitor, so exposure may rise slightly, with possible increases in nausea, dizziness or blood pressure.
What this interaction means in plain words
Eletriptan and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eletriptan belongs to Central Nervous System; Zafirlukast belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by zafirlukast may reduce eletriptan first-pass metabolism.
What to do
Use the standard eletriptan dose and monitor for adverse effects. Avoid repeat dosing within 2 hours if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Zafirlukast?
MediHelp rates the interaction as minor. Eletriptan and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eletriptan is a sensitive CYP3A4 substrate, and strong inhibitors are contraindicated. Zafirlukast is only a weak inhibitor, so exposure may rise slightly, with possible increases in nausea, dizziness or blood pressure.
How serious is the interaction between Eletriptan and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the standard eletriptan dose and monitor for adverse effects. Avoid repeat dosing within 2 hours if symptoms occur.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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