Drug interactions
Eletriptan + Ziprasidone
Severity: Moderate
Eletriptan and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs affect serotonergic signalling, and ziprasidone has serotonin receptor activity. Serotonin syndrome and neuroleptic malignant syndrome have been described with combinations of antipsychotics and serotonergic agents, although the risk with triptans is thought to be low.
What this interaction means in plain words
Eletriptan and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects, with dopamine blockade as a theoretical contributor to neuroleptic malignant syndrome.
What to do
The combination can be used with awareness of the risk. Counsel patients to report agitation, tremor, fever, sweating or muscle rigidity, and stop the drugs if serotonin toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eletriptan and Ziprasidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Ziprasidone?
MediHelp rates the interaction as moderate. Eletriptan and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs affect serotonergic signalling, and ziprasidone has serotonin receptor activity. Serotonin syndrome and neuroleptic malignant syndrome have been described with combinations of antipsychotics and serotonergic agents, although the risk with triptans is thought to be low.
How serious is the interaction between Eletriptan and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination can be used with awareness of the risk. Counsel patients to report agitation, tremor, fever, sweating or muscle rigidity, and stop the drugs if serotonin toxicity is suspected.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
