Drug interactions
Eliglustat + Fluphenazine
Severity: Major
Eliglustat and Fluphenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits CYP2D6 and can raise fluphenazine concentrations, increasing the risk of sedation, extrapyramidal effects and QT prolongation. Eliglustat itself can prolong ECG intervals at high concentrations, adding to the cardiac risk.
What this interaction means in plain words
Eliglustat and Fluphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Fluphenazine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by eliglustat reduces fluphenazine clearance, with additive QT effects.
What to do
Consider reducing the fluphenazine dose and monitor for toxicity. Obtain an ECG and correct electrolytes before and during combined use.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eliglustat and Fluphenazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Fluphenazine?
MediHelp rates the interaction as major. Eliglustat and Fluphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat inhibits CYP2D6 and can raise fluphenazine concentrations, increasing the risk of sedation, extrapyramidal effects and QT prolongation. Eliglustat itself can prolong ECG intervals at high concentrations, adding to the cardiac risk.
How serious is the interaction between Eliglustat and Fluphenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the fluphenazine dose and monitor for toxicity. Obtain an ECG and correct electrolytes before and during combined use.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
