Drug interactions
Eliglustat + Fluvoxamine
Severity: Major
Eliglustat and Fluvoxamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is cleared by CYP2D6 and CYP3A4, and fluvoxamine inhibits both, which can substantially raise eliglustat levels. This increases the risk of PR, QRS and QT prolongation and arrhythmia.
What this interaction means in plain words
Eliglustat and Fluvoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Fluvoxamine belongs to Central Nervous System.
Why it happens
Combined CYP2D6 and CYP3A4 inhibition raises eliglustat exposure with additive QT effects.
What to do
Avoid the combination, or reduce the eliglustat dose per labeling and monitor ECG. Choose an antidepressant without these inhibitory effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Fluvoxamine?
MediHelp rates the interaction as major. Eliglustat and Fluvoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat is cleared by CYP2D6 and CYP3A4, and fluvoxamine inhibits both, which can substantially raise eliglustat levels. This increases the risk of PR, QRS and QT prolongation and arrhythmia.
How serious is the interaction between Eliglustat and Fluvoxamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, or reduce the eliglustat dose per labeling and monitor ECG. Choose an antidepressant without these inhibitory effects.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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