Drug interactions
Eliglustat + Haloperidol
Severity: Major
Eliglustat and Haloperidol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is a CYP2D6 inhibitor and substrate, and can raise eliglustat concentrations. Eliglustat itself prolongs PR, QRS and QT intervals at high exposure, so higher levels increase arrhythmia risk.
What this interaction means in plain words
Eliglustat and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Haloperidol belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by haloperidol raising eliglustat exposure, with additive QT effects.
What to do
Avoid if possible; if used, reduce eliglustat dose per labeling and monitor ECG. Do not use if a CYP3A inhibitor is also given.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Haloperidol?
MediHelp rates the interaction as major. Eliglustat and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Haloperidol is a CYP2D6 inhibitor and substrate, and can raise eliglustat concentrations. Eliglustat itself prolongs PR, QRS and QT intervals at high exposure, so higher levels increase arrhythmia risk.
How serious is the interaction between Eliglustat and Haloperidol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used, reduce eliglustat dose per labeling and monitor ECG. Do not use if a CYP3A inhibitor is also given.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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