Drug interactions
Eliglustat + Liposomal doxorubicin
Severity: Minor
Eliglustat and Liposomal doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and CYP2D6 and could increase exposure to doxorubicin. Liposomal encapsulation limits the dependence on these pathways, so the effect is likely small. Eliglustat also has cardiac conduction effects, so the combined cardiac risk deserves some awareness.
What this interaction means in plain words
Eliglustat and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eliglustat belongs to Miscellaneous; Liposomal doxorubicin belongs to Oncology.
Why it happens
Eliglustat inhibits P-glycoprotein efflux and CYP2D6 metabolism, which may modestly raise doxorubicin levels.
What to do
Monitor for myelosuppression, mucositis and cardiac toxicity. Check an ECG if the patient has cardiac risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Liposomal doxorubicin?
MediHelp rates the interaction as minor. Eliglustat and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat inhibits P-glycoprotein and CYP2D6 and could increase exposure to doxorubicin. Liposomal encapsulation limits the dependence on these pathways, so the effect is likely small. Eliglustat also has cardiac conduction effects, so the combined cardiac risk deserves some awareness.
How serious is the interaction between Eliglustat and Liposomal doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myelosuppression, mucositis and cardiac toxicity. Check an ECG if the patient has cardiac risk factors.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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