Drug interactions
Eliglustat + Loperamide
Severity: Moderate
Eliglustat and Loperamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-gp and can raise loperamide exposure, and both drugs may prolong the QT interval. Together they could increase arrhythmia risk, particularly in patients with cardiac disease.
What this interaction means in plain words
Eliglustat and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Loperamide belongs to Gastrointestinal Tract.
Why it happens
P-gp inhibition by eliglustat increases loperamide levels, with additive QT prolongation.
What to do
Use the lowest effective loperamide dose and avoid exceeding labeled limits. Obtain an ECG in patients with QT risk factors and correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Loperamide?
MediHelp rates the interaction as moderate. Eliglustat and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits P-gp and can raise loperamide exposure, and both drugs may prolong the QT interval. Together they could increase arrhythmia risk, particularly in patients with cardiac disease.
How serious is the interaction between Eliglustat and Loperamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective loperamide dose and avoid exceeding labeled limits. Obtain an ECG in patients with QT risk factors and correct electrolyte abnormalities.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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