Drug interactions
Eliglustat + Perphenazine
Severity: Major
Eliglustat and Perphenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits CYP2D6, the main enzyme metabolizing perphenazine, and may raise perphenazine concentrations. Both drugs can prolong the QT interval, so the combination raises the risk of arrhythmia and extrapyramidal adverse effects.
What this interaction means in plain words
Eliglustat and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Perphenazine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by eliglustat reduces perphenazine clearance, with additive QT prolongation.
What to do
Consider reducing the perphenazine dose and monitor ECG, electrolytes and for adverse effects. Avoid in patients with long QT or other QT-prolonging drugs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Perphenazine?
MediHelp rates the interaction as major. Eliglustat and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat inhibits CYP2D6, the main enzyme metabolizing perphenazine, and may raise perphenazine concentrations. Both drugs can prolong the QT interval, so the combination raises the risk of arrhythmia and extrapyramidal adverse effects.
How serious is the interaction between Eliglustat and Perphenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the perphenazine dose and monitor ECG, electrolytes and for adverse effects. Avoid in patients with long QT or other QT-prolonging drugs.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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