Drug interactions
Eliglustat + Pravastatin
Severity: Minor
Eliglustat and Pravastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat may slightly raise pravastatin concentrations via P-glycoprotein inhibition. The clinical effect is expected to be small.
What this interaction means in plain words
Eliglustat and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eliglustat belongs to Miscellaneous; Pravastatin belongs to Cardiovascular.
Why it happens
Eliglustat inhibits P-glycoprotein-mediated efflux of pravastatin.
What to do
No routine change is needed; monitor for muscle symptoms and reduce the pravastatin dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Pravastatin?
MediHelp rates the interaction as minor. Eliglustat and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat may slightly raise pravastatin concentrations via P-glycoprotein inhibition. The clinical effect is expected to be small.
How serious is the interaction between Eliglustat and Pravastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for muscle symptoms and reduce the pravastatin dose if they occur.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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