Drug interactions
Eliglustat + Solifenacin
Severity: Moderate
Eliglustat and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat can prolong PR, QRS, and QT intervals at high exposures, and solifenacin has a dose-related QT effect. Together they may raise arrhythmia risk, especially in patients with cardiac disease.
What this interaction means in plain words
Eliglustat and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation; eliglustat also inhibits CYP2D6 and P-gp, though solifenacin is mainly a CYP3A4 substrate.
What to do
Obtain a baseline ECG and monitor it, keep electrolytes normal, and consider an alternative bladder agent in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Solifenacin?
MediHelp rates the interaction as moderate. Eliglustat and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat can prolong PR, QRS, and QT intervals at high exposures, and solifenacin has a dose-related QT effect. Together they may raise arrhythmia risk, especially in patients with cardiac disease.
How serious is the interaction between Eliglustat and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it, keep electrolytes normal, and consider an alternative bladder agent in patients with cardiac disease.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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