Drug interactions
Eliglustat + Testosterone
Severity: Minor
Eliglustat and Testosterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and could raise exposure to substrates. Testosterone is a weak P-gp substrate, so the clinical effect is probably small.
What this interaction means in plain words
Eliglustat and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eliglustat belongs to Miscellaneous; Testosterone belongs to Endocrine.
Why it happens
P-glycoprotein inhibition by eliglustat may slightly increase testosterone absorption and exposure.
What to do
No routine adjustment; monitor for androgenic adverse effects or hematocrit if testosterone therapy is long-term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Testosterone
- Testosterone + Warfarin Major
- Androstenedione + Testosterone Moderate
- Betamethasone + Testosterone Moderate
- Carbamazepine + Testosterone Moderate
- Corticotropin + Testosterone Moderate
- Cortisone + Testosterone Moderate
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Testosterone?
MediHelp rates the interaction as minor. Eliglustat and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat inhibits P-glycoprotein and could raise exposure to substrates. Testosterone is a weak P-gp substrate, so the clinical effect is probably small.
How serious is the interaction between Eliglustat and Testosterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for androgenic adverse effects or hematocrit if testosterone therapy is long-term.
What other medicines interact with Testosterone?
MediHelp also lists interactions of Testosterone with, for example, Warfarin, Androstenedione, Betamethasone. The full list is on the Testosterone page.
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