Drug interactions
Eliglustat + Voriconazole
Severity: Contraindicated
Eliglustat and Voriconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole increases eliglustat concentrations, which can prolong PR, QRS and QT intervals and cause arrhythmias. The risk is greatest in CYP2D6 poor or intermediate metabolizers and when combined with CYP2D6 inhibitors.
What this interaction means in plain words
Eliglustat and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eliglustat belongs to Miscellaneous; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, a secondary clearance pathway for eliglustat, raising its exposure.
What to do
Avoid in CYP2D6 intermediate or poor metabolizers and with any CYP2D6 inhibitor; in extensive metabolizers reduce eliglustat to 84 mg once daily and monitor ECG.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Voriconazole?
MediHelp rates the interaction as contraindicated. Eliglustat and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole increases eliglustat concentrations, which can prolong PR, QRS and QT intervals and cause arrhythmias. The risk is greatest in CYP2D6 poor or intermediate metabolizers and when combined with CYP2D6 inhibitors.
How serious is the interaction between Eliglustat and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in CYP2D6 intermediate or poor metabolizers and with any CYP2D6 inhibitor; in extensive metabolizers reduce eliglustat to 84 mg once daily and monitor ECG.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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