Drug interactions
Elranatamab + Fluvoxamine
Severity: Moderate
Elranatamab and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elranatamab causes cytokine release syndrome, and elevated cytokines can temporarily suppress CYP enzyme activity. This may raise fluvoxamine exposure in the period from step-up dosing through CRS, although fluvoxamine has a wide margin of safety.
What this interaction means in plain words
Elranatamab and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elranatamab belongs to Oncology; Fluvoxamine belongs to Central Nervous System.
Why it happens
Cytokine-mediated suppression of CYP activity may reduce fluvoxamine clearance.
What to do
Monitor for fluvoxamine adverse effects such as nausea, sedation and serotonergic symptoms during step-up dosing and CRS, and reduce the dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Elranatamab
- Elranatamab + Ergotamine Major
- Elranatamab + Pimozide Major
- Bendamustine + Elranatamab Moderate
- Carbamazepine + Elranatamab Moderate
- Clomipramine + Elranatamab Moderate
- Clozapine + Elranatamab Moderate
Frequently asked questions
Can I take Elranatamab with Fluvoxamine?
MediHelp rates the interaction as moderate. Elranatamab and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elranatamab causes cytokine release syndrome, and elevated cytokines can temporarily suppress CYP enzyme activity. This may raise fluvoxamine exposure in the period from step-up dosing through CRS, although fluvoxamine has a wide margin of safety.
How serious is the interaction between Elranatamab and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for fluvoxamine adverse effects such as nausea, sedation and serotonergic symptoms during step-up dosing and CRS, and reduce the dose if they occur.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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