Drug interactions
Elranatamab + Tacrolimus
Severity: Moderate
Elranatamab and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release syndrome from elranatamab can transiently suppress CYP enzyme activity and raise tacrolimus concentrations. This may cause tacrolimus toxicity around step-up dosing and during CRS.
What this interaction means in plain words
Elranatamab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elranatamab belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Cytokine-mediated downregulation of CYP3A4 reduces tacrolimus metabolism.
What to do
Monitor tacrolimus trough levels and renal function closely during step-up dosing and any CRS, adjusting the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Elranatamab
- Elranatamab + Ergotamine Major
- Elranatamab + Pimozide Major
- Bendamustine + Elranatamab Moderate
- Carbamazepine + Elranatamab Moderate
- Clomipramine + Elranatamab Moderate
- Clozapine + Elranatamab Moderate
Frequently asked questions
Can I take Elranatamab with Tacrolimus?
MediHelp rates the interaction as moderate. Elranatamab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release syndrome from elranatamab can transiently suppress CYP enzyme activity and raise tacrolimus concentrations. This may cause tacrolimus toxicity around step-up dosing and during CRS.
How serious is the interaction between Elranatamab and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function closely during step-up dosing and any CRS, adjusting the dose as needed.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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